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neuroadaptations in human chronic alcoholics dysregulation of the nf-κb system在人类神经慢性酗酒者nf-κb系统的失调
Neuroadaptations in Human Chronic Alcoholics: Dysregulation of the NF-kB System ¨ 1 1 1 1 2 3 3 Anna Okvist , Sofia Johansson , Alexander Kuzmin , Igor Bazov , Roxana Merino-Martinez , Igor Ponomarev , R. Dayne Mayfield , 3 4 4 4 5,6 1 ¨ 1 1,7. R. Adron Harris , Donna Sheedy , Therese Garrick , Clive Harper , Yasmin L. Hurd , Lars Terenius , Tomas J. Ekstrom , Georgy Bakalkin *, Tatjana Yakovleva1,7. 1The Section of Alcohol and Drug Dependence Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden, 2 Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden, 3 Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas, United States of America, 4 Discipline of Pathology, University of Sydney, Sydney, New South Wales, Australia, 5 Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America, 6 Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York, United States of America, 7 Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden Background. Alcohol dependence and associated cognitive impairments apparently result from neuroadaptations to chronic alcohol consumption involving changes in expression of multiple genes. Here we investigated whether transcription factors of Nuclear Factor-kappaB (NF-kB) family, controlling neuronal plasticity and neurodegeneration, are involved in these adaptations in human c
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