neurocognition, insight and medication nonadherence in schizophrenia a structural equation modeling approach在精神分裂症的神经认知、洞察力和药物治疗不依从结构方程建模的方法.pdfVIP

Neurocognition, Insight and Medication Nonadherence in Schizophrenia: A Structural Equation Modeling Approach 1 2 3 1 1 Laurent Boyer *, Michel Cermolacce , Daniel Dassa , Jessica Fernandez , Mohamed Boucekine , 1,2 2 1,2 1 1,2 Raphaelle Richieri , Florence Vaillant , Remy Dumas , Pascal Auquier , Christophe Lancon 1 Aix-Marseille University, EA 3279 – Public Health, Chronic Diseases and Quality of Life - Research Unit, Marseille, France, 2 Department of Psychiatry, Sainte-Marguerite University Hospital, Marseille, France, 3 Department of Psychiatry, La Conception University Hospital, Marseille, France Abstract Objective: The aim of this study was to examine the complex relationships among neurocognition, insight and nonadherence in patients with schizophrenia. Methods: Design: Cross-sectional study. Inclusion criteria: Diagnosis of schizophrenia according to the DSM-IV-TR criteria. Data collection: Neurocognition was assessed using a global approach that addressed memory, attention, and executive functions; insight was analyzed using the multidimensional ‘Scale to assess Unawareness of Mental Disorder;’ and nonadherence was measured using the multidimensional ‘Medication Adherence Rating Scale.’ Analysis: Structural equation modeling (SEM) was applied to examine the non-straightforward relationships among the following latent variables: neurocognition, ‘awareness of positive symptoms’ and ‘negative symptoms’, ‘awareness of me