multiple ets family proteins regulate pf4 gene expression by binding to the same ets binding site多个ets家族蛋白基因表达调节pf4通过绑定到相同的ets结合位点.pdfVIP

Multiple ETS Family Proteins Regulate PF4 Gene Expression by Binding to the Same ETS Binding Site 1 . 1. 1 2 1 Yoshiaki Okada * , Haruaki Nobori , Mikiko Shimizu , Miho Watanabe , Masaaki Yonekura , Tomoko 1 1 1 1 1 1 Nakai , Yuko Kamikawa , Atsuko Wakimura , Nobuaki Funahashi , Hiroki Naruse , Ayako Watanabe , 1 1 3 4 5 Daisuke Yamasaki , So-ichiro Fukada , Kazuta Yasui , Kayoko Matsumoto , Takahiro Sato , Kenji 6 6 7 1,2 Kitajima , Toru Nakano , William C. Aird , Takefumi Doi 1 Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, 2 Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, 3 Department of Research, Osaka Red Cross Blood Center, Osaka, Japan, 4 Division of Cord Blood Cell Processing, Osaka Red Cross Blood Center, Osaka, Japan, 5 Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University, Tokyo, Japan, 6 Department of Pathology, Medical School, Osaka University, Osaka, Japan, 7 Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America Abstract In previous studies on the mechanism underlying megakaryocyte-specific gene expression, several ETS motifs were found in each megakaryocyte-specific gene promoter. Although these studies suggested that several ETS family proteins regulate megakaryocyte-specific gen