neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus神经母细胞瘤细胞系包含多能肿瘤启动细胞容易有针对性的溶瘤细胞的病毒.pdfVIP

Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus 1,2,4,5 2 1,2,4,5 1,4 3 Yonatan Y. Mahller , Jon P. Williams , William H. Baird , Bryan Mitton , Jonathan Grossheim , 6 2 2 1,2 Yoshinaga Saeki , Jose A. Cancelas , Nancy Ratner , Timothy P. Cripe * 1 Division of Hematology and Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, 2 Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, 3 Division of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, 4 Physician Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, 5 Graduate Program of Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, 6 Dardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America Abstract Background: Although disease remission can frequently be achieved for patients with neuroblastoma, relapse is common. The cancer stem cell theory suggests that rare tumorigenic cells, resistant to conventional therapy, are responsible for relapse. If true for neuroblastoma, improved cure rates may only be achieved via identification and therapeutic targeting of the neuroblastoma tumor initiating cell. Based on