有哪些信誉好的足球投注网站multiple independent genetic factors at nos1ap modulate the qt interval in a multi-ethnic population多个独立的遗传因素在nos1ap调节qt间隔在一个多民族人口.pdfVIP
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multiple independent genetic factors at nos1ap modulate the qt interval in a multi-ethnic population多个独立的遗传因素在nos1ap调节qt间隔在一个多民族人口
Multiple Independent Genetic Factors at NOS1AP Modulate the QT Interval in a Multi-Ethnic Population 1 2,3 4 5 6 7 Dan E. Arking *, Amit Khera , Chao Xing , W. H. Linda Kao , Wendy Post , Eric Boerwinkle , Aravinda Chakravarti1 1 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 3 Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 4 McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 5 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 6 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 7 Human Genetics Center and Division of Epidemiology, The University of Texas, Houston, Texas, United States of America Abstract Extremes of electrocardiographic QT interval are associated with increased risk for sudden cardiac death (SCD); thus, identification and characterization of genetic variants that modulate QT interval may elucidate the underlying etiology of SCD. Previous studies have revealed an association between a common genetic variant in NOS1AP and QT interval in populations of European ancestry, but this finding has not been extended to other ethnic populations. We sought to characterize the effects of NOS1AP genetic variants on QT interval in the multi-ethnic population-based Dallas He
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