multiple cytochrome p450 genes their constitutive overexpression and permethrin induction in insecticide resistant mosquitoes, culex quinquefasciatus多种本构超表达和氯菊酯诱导细胞色素p450基因杀虫剂抗性的蚊子,这种致倦库蚊.pdfVIP

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multiple cytochrome p450 genes their constitutive overexpression and permethrin induction in insecticide resistant mosquitoes, culex quinquefasciatus多种本构超表达和氯菊酯诱导细胞色素p450基因杀虫剂抗性的蚊子,这种致倦库蚊.pdf

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multiple cytochrome p450 genes their constitutive overexpression and permethrin induction in insecticide resistant mosquitoes, culex quinquefasciatus多种本构超表达和氯菊酯诱导细胞色素p450基因杀虫剂抗性的蚊子,这种致倦库蚊

Multiple Cytochrome P450 Genes: Their Constitutive Overexpression and Permethrin Induction in Insecticide Resistant Mosquitoes, Culex quinquefasciatus 1 . 1. 1 1 2 Nannan Liu * , Ting Li , William R. Reid , Ting Yang , Lee Zhang 1 Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama, United States of America, 2 Genomics and Sequencing Laboratory, Auburn University, Auburn, Alabama, United States of America Abstract Four cytochrome P450 cDNAs, CYP6AA7, CYP9J40, CYP9J34, and CYP9M10, were isolated from mosquitoes, Culex quinquefasciatus. The P450 gene expression and induction by permethrin were compared for three different mosquito populations bearing different resistance phenotypes, ranging from susceptible (S-Lab), through intermediate (HAmCqG0, the field parental population) to highly resistant (HAmCqG8, the 8th generation of permethrin selected offspring of HAmCqG0). A strong correlation was found for P450 gene expression with the levels of resistance and following permethrin selection at the larval stage of mosquitoes, with the highest expression levels identified in HAmCqG8, suggesting the importance of CYP6AA7, CYP9J40, CYP9J34, and CYP9M10 in the permethrin resistance of larva mosquitoes. Only CYP6AA7 showed a significant overexpression in HAmCqG8 adult mosquitoes. Other P450 genes had similar expression levels among the mosquito populations tested, suggesting different P450 genes may be involved in the response to insecticide pressure in different developmental stages. The expression of CYP6AA7, CYP9J34, and CYP9M10 was further induced by permethrin in resistant mosquitoes. Taken together, these re