neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies神经干细胞的肿瘤特异性的治疗性抗体的新平台.pdfVIP

neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies神经干细胞的肿瘤特异性的治疗性抗体的新平台.pdf

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neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies神经干细胞的肿瘤特异性的治疗性抗体的新平台

Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies 1 1 2 1 3 Richard T. Frank *, Marissa Edmiston , Stephen E. Kendall , Joseph Najbauer , Chia-Wei Cheung , 3 1 6,7 2 5 Thewodros Kassa , Marianne Z. Metz , Seung U. Kim , Carlotta A. Glackin , Anna M. Wu , Paul J. Yazaki3, Karen S. Aboody1,4* 1 Divisions of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America, 2 Department of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America, 3 Department of Cancer Immunotherapy and Tumor Immunology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America, 4 Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America, 5 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 6 Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada, 7 Institute for Regenerative Medicine, Gachon University Gil Hospital, Inchon, Korea Abstract Background: Recombinant monoclonal antibodies have emerged as important tools for cancer therapy. Despite the promise shown by antibody-based therapies, the large molecular

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