有哪些信誉好的足球投注网站muscarinic and nicotinic modulation of thalamo-prefrontal cortex synaptic pasticity in vivo毒蕈碱的和烟碱调制thalamo-prefrontal皮层突触pasticity体内.pdfVIP
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muscarinic and nicotinic modulation of thalamo-prefrontal cortex synaptic pasticity in vivo毒蕈碱的和烟碱调制thalamo-prefrontal皮层突触pasticity体内
Muscarinic and Nicotinic Modulation of Thalamo- Prefrontal Cortex Synaptic Pasticity In Vivo 1 1 1 Lezio Soares Bueno-Junior , Cleiton Lopes-Aguiar , Rafael Naime Ruggiero , Rodrigo Neves Romcy- 1,2 ˜ 1 Pereira *, Joao Pereira Leite ˜ ˜ ˜ ˜ 1 Department of Neuroscience and Behavioral Sciences, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 2 Brain Institute, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil Abstract The mediodorsal nucleus of the thalamus (MD) is a rich source of afferents to the medial prefrontal cortex (mPFC). Dysfunctions in the thalamo-prefrontal connections can impair networks implicated in working memory, some of which are affected in Alzheimer disease and schizophrenia. Considering the importance of the cholinergic system to cortical functioning, our study aimed to investigate the effects of global cholinergic activation of the brain on MD-mPFC synaptic plasticity by measuring the dynamics of long-term potentiation (LTP) and depression (LTD) in vivo. Therefore, rats received intraventricular injections either of the muscarinic agonist pilocarpine (PILO; 40 nmol/mL), the nicotinic agonist nicotine (NIC; 320 nmol/mL), or vehicle. The injections were administered prior to either thalamic high-frequency (HFS) or low-frequency stimulation (LFS). Test pulses were applied to MD for 30 min during baseline and 240 min after HFS or LFS, while field postsynaptic potentials were recorded in the mPFC. The transient oscillatory effects of
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