molecular epidemiology of endemic human t-lymphotropic virus type 1 in a rural community in guinea-bissau的分子流行病学流行人类t细胞白血病病毒1型在几内亚比绍的农村社区.pdfVIP

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molecular epidemiology of endemic human t-lymphotropic virus type 1 in a rural community in guinea-bissau的分子流行病学流行人类t细胞白血病病毒1型在几内亚比绍的农村社区.pdf

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molecular epidemiology of endemic human t-lymphotropic virus type 1 in a rural community in guinea-bissau的分子流行病学流行人类t细胞白血病病毒1型在几内亚比绍的农村社区

Molecular Epidemiology of Endemic Human T- Lymphotropic Virus Type 1 in a Rural Community in Guinea-Bissau Carla van Tienen1,2*, Thushan I. de Silva1,3, Luiz Carlos Junior Alcantara4,5, Clayton O. Onyango1,6, 1 1,7 1 8 1 Sheikh Jarju , Nato Gonc¸alves , Tim Vincent , Peter Aaby , Hilton Whittle , Maarten Schim van der Loeff9, Matthew Cotten1,10 1Virology, Medical Research Council, Fajara, The Gambia, 2 Medical Microbiology Infectious Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands, 3 UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom, 4 Public Health Advanced Laboratory, Gonc¸alo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil, 5 Bahia School of Medicine and Public Health Foundation for Science Development, ´ ´ Salvador, Bahia, Brazil, 6 KEMRI-Wellcome Trust Programme, Kilifi, Kenya, 7 Projecto de Saude de Bandim, Bissau, Guinea-Bissau, 8 Projecto de Saude de Bandim, Indepth Network, Bissau, Guinea-Bissau, 9 Health Service of Amsterdam (GGD) and Academic Medical Centre, Amsterdam, The Netherlands, 10 Wellcome Trust Genome Campus, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom Abstract Background: Human T-Lymphotropic Virus Type 1 (HTLV-1) infection causes lethal adult T-cell leukemia (ATL) and severely debilitating HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in up to 5% of infected adults. HTLV-1 is endemic in parts of Africa and the highest prevalence in West Africa (5%) has been reported in Caio, a rural area in the North-West of Guinea-Bissau. It is not known which HTLV-1 v