molecular epidemiology of hiv-1 transmission in a cohort of hiv-1 concordant heterosexual couples from dakar, senegal分子流行病学的hiv - 1传输队列的hiv - 1整合异性夫妇从达喀尔,塞内加尔.pdfVIP

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molecular epidemiology of hiv-1 transmission in a cohort of hiv-1 concordant heterosexual couples from dakar, senegal分子流行病学的hiv - 1传输队列的hiv - 1整合异性夫妇从达喀尔,塞内加尔.pdf

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molecular epidemiology of hiv-1 transmission in a cohort of hiv-1 concordant heterosexual couples from dakar, senegal分子流行病学的hiv - 1传输队列的hiv - 1整合异性夫妇从达喀尔,塞内加尔

Molecular Epidemiology of HIV-1 Transmission in a Cohort of HIV-1 Concordant Heterosexual Couples from Dakar, Senegal 1 1 1 2 3 Wim Jennes *, Jordan K. Kyongo , Evelyn Vanhommerig , Makhtar Camara , Sandra Coppens , 4 2 3 1 Moussa Seydi , Souleymane Mboup , Leo Heyndrickx , Luc Kestens 1 Laboratory of Immunology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, 2 Laboratory of Immunology, Department of Bacteriology-Virology, Centre Hospitalier Universitaire Le Dantec, Cheikh Anta Diop University, Dakar, Senegal, 3 Laboratory of Virology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, 4 Department of Infectious Diseases, Centre Hospitalier Universitaire Fann, Cheikh Anta Diop University, Dakar, Senegal Abstract Background: A large number of HIV-1 infections in Africa occur in married couples. The predominant direction of intracouple transmission and the principal external origins of infection remain important issues of debate. Methods: We investigated HIV-1 transmission in 46 HIV-1 concordant positive couples from Dakar, Senegal. Intracouple transmission was confirmed by maximum-likelihood phylogenetic analysis and pairwise distance comparisons of HIV-1 env gp41 sequences from both partners. Standardized interview data were used to deduce the direction as well as the external sources of the intracouple transmissions. Results: Conservative molecular analyses showed linked viruses in 34 (74%) couples, unlinked viruses in 6 (13%) couples, and indeterminate results for 6 (13%) couples. The