molecular epidemiology of human immunodeficiency virus type 1 in guangdong province of southern china分子流行病学的人类免疫缺陷病毒1型在中国南部的广东省.pdfVIP

Molecular Epidemiology of Human Immunodeficiency Virus Type 1 in Guangdong Province of Southern China 1,2. 3. 1 4 1 1 3 Song Chen , Weiping Cai , Jingyang He , Nicole Vidal , Chunhui Lai , Weizhong Guo , Haolan He , 3 1 4 4 2 1,4 Xiejie Chen , Linsheng Fu , Martine Peeters , Eric Delaporte , Jean-Marie Andrieu , Wei Lu * 1 Sino-French Collaborative Laboratory, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou, China, 2 Laboratoire d’Oncologie et Virologie ´ ´ Moleculaire, Universite Paris Descartes, Paris, France, 3 Guangzhou Hospital of Infectious Diseases, Guangzhou, China, 4 UMI 233, Institut de Recherche pour le ´ ´ Developpement and Universite de Monpellier 1, Monpellier, France Abstract Background: Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, the molecular characteristics of such a regional HIV-1 epidemic remained unknown. Methodology/Principal Findings: By sequencing of HIV-1 pol/env genes and phylogenetic analysis, we performed a molecular epidemiologic study in a representative subset (n = 200) of the 508 HIV-1-seropositive individuals followed up at the center for HIV/AIDS care and treatment of Guangzhou Hospital of Infectious Diseases. Of 157 samples (54.1% heterosexual acquired adults, 20.4% needle-sharing dru