molecular epidemiology of influenza a(h1n1)pdm09 viruses from pakistan in 2009–2010甲型流感(h1n1)pdm09病毒的分子流行病学从巴基斯坦在2009 - 2010年.pdfVIP

Molecular Epidemiology of Influenza A(H1N1)pdm09 Viruses from Pakistan in 2009–2010 1 1 1 1 Uzma Bashir Aamir , Nazish Badar , Muhammad Rashid Mehmood , Nadia Nisar , Rana 1 1 1 2 1 Muhammad Suleman , Shehzad Shaukat , Salman Sharif , Jaleel Kamran , Syed Sohail Zahoor Zaidi *, 2 3 3 3 3 Birjees Mazher Kazi , Larisa Gubareva , Xiyan Xu , Rebecca Garten , Alexander Klimov 1 Department of Virology, Public Health Laboratories Division, National Institute of Health, Chak Shahzad, Islamabad, Pakistan, 2 Public Health Laboratories Division, National Institute of Health, Chak Shahzad, Islamabad, Pakistan, 3 Influenza Division, Centers for Disease Control, Atlanta, Georgia, United States of America Abstract Background: In early 2009, a novel influenza A(H1N1) virus that emerged in Mexico and United States rapidly disseminated worldwide. The spread of this virus caused considerable morbidity with over 18000 recorded deaths. The new virus was found to be a reassortant containing gene segments from human, avian and swine influenza viruses. Methods/Results: The first case of human infection with A(H1N1)pdm09 in Pakistan was detected on 18th June 2009. Since then, 262 laboratory-confirmed cases have been detected during various outbreaks with 29 deaths (as of 31st August 2010). The peak of the epidemic was observed in December with over 51% of total respiratory cases positive for influenza. Representative isolates from Pakistan viruses were sequenced and analyzed antigenical