有哪些信誉好的足球投注网站murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain小鼠巨细胞病毒感染神经干细胞改变发展中大脑的神经发生.pdfVIP
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murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain小鼠巨细胞病毒感染神经干细胞改变发展中大脑的神经发生
Murine Cytomegalovirus Infection of Neural Stem Cells Alters Neurogenesis in the Developing Brain 1 2 1 1 Manohar B. Mutnal , Maxim C-J. Cheeran , Shuxian Hu , James R. Lokensgard * 1 Neuroimmunology Laboratory, Department of Medicine, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota, United States of America, 2 Department of Veterinary Population Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America Abstract Background: Congenital cytomegalovirus (CMV) brain infection causes serious neuro-developmental sequelae including: mental retardation, cerebral palsy, and sensorineural hearing loss. But, the mechanisms of injury and pathogenesis to the fetal brain are not completely understood. The present study addresses potential pathogenic mechanisms by which this virus injures the CNS using a neonatal mouse model that mirrors congenital brain infection. This investigation focused on, analysis of cell types infected with mouse cytomegalovirus (MCMV) and the pattern of injury to the developing brain. Methodology/Principal Findings: We used our MCMV infection model and a multi-color flow cytometry approach to quantify the effect of viral infection on the developing brain, identifying specific target cells and the consequent effect on neurogenesis. In this study, we show that neural stem cells (NSCs) and neuronal precursor cells are the principal target cells for MCMV in the developing brain. In addition, viral infection was demonstrated to cause a loss of NSCs expressing CD133 and nestin. We also showed that infection of neonates leads to subsequent abnormal brain development as indicated by loss of CD24(hi) cells that incorporated BrdU. This neonatal bra
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