multispacer sequence typing relapsing fever borreliae in africamultispacer序列输入回归热borreliae在非洲.pdfVIP

Multispacer Sequence Typing Relapsing Fever Borreliae in Africa 1 1 2 3 3 Elbir Haitham , Gregory Gimenez , Cheikh Sokhna , Kassahun Desalegn Bilcha , Jemal Ali , 4 5 1 1 Stephen C. Barker , Sally J. Cutler , Didier Raoult , Michel Drancourt * ´ ´ ´ ´ ´ 1 Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR CNRS 6236 IRD 198, Faculte de Medecine, Mediterranee Infection, Aix-Marseille ´ ´ ´ ´ Universite, Marseille, France, 2 Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR CNRS 6236 IRD 198, Mediterranee Infection, Aix- ´ Marseille Universite, Dakar, Senegal, 3 College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, 4 Parasitology Section, School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia, 5 School of Health, Sports and Bioscience, University of East London, London, United Kingdom Abstract Background: In Africa, relapsing fevers are neglected arthropod-borne infections caused by closely related Borrelia species. They cause mild to deadly undifferentiated fever particularly severe in pregnant women. Lack of a tool to genotype these Borrelia organisms limits knowledge regarding their reservoirs and their epidemiology. Methodology/Principal Findings: Genome sequence analysis of Borrelia crocidurae, Borrelia duttonii and Borrelia recur