有哪些信誉好的足球投注网站murine leukemias with retroviral insertions at lmo2 are predictive of the leukemias induced in scid-x1 patients following retroviral gene therapy小鼠白血病与逆转录病毒插入在lmo2预测scid-x1白血病诱导的逆转录病毒基因治疗后患者.pdfVIP
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murine leukemias with retroviral insertions at lmo2 are predictive of the leukemias induced in scid-x1 patients following retroviral gene therapy小鼠白血病与逆转录病毒插入在lmo2预测scid-x1白血病诱导的逆转录病毒基因治疗后患者
Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy ´ 1,2 3 1,2 1,2 4 5 Utpal P. Dave *, Keiko Akagi , Rati Tripathi , Susan M. Cleveland , Mary A. Thompson , Ming Yi , 5 6 7 7 Robert Stephens , James R. Downing , Nancy A. Jenkins , Neal G. Copeland 1 Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 2 Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 3 Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland, United States of America, 4 Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, 5 Advanced Biomedical Computing Center, National Cancer Institute, Frederick, Maryland, United States of America, 6 St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, 7 Institute of Molecular and Cell Biology, Biopolis, Singapore, Singapore Abstract Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional mutations at LMO2. Genetic evidence also suggests a role for IL2RG in tumor formation, although this remains controversial. Here, we show that the genes and signaling pathways deregulated in murine leukemias with retroviral insertions at Lmo2 are s
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