有哪些信誉好的足球投注网站murine pancreatic adenocarcinoma dampens ship-1 expression and alters mdsc homeostasis and function小鼠胰腺腺癌抑制了ship 1表达和改变mdsc体内平衡和功能.pdfVIP
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murine pancreatic adenocarcinoma dampens ship-1 expression and alters mdsc homeostasis and function小鼠胰腺腺癌抑制了ship 1表达和改变mdsc体内平衡和功能
Murine Pancreatic Adenocarcinoma Dampens SHIP-1 Expression and Alters MDSC Homeostasis and Function 2 1 2 1 1 Shari Pilon-Thomas , Nadine Nelson , Nasreen Vohra , Maya Jerald , Laura Pendleton , Karoly 1 1 Szekeres , Tomar Ghansah * 1 Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, Florida, United States of America, 2 Immunology Program, H. Lee Moffitt Comprehensive Cancer Center and Research Institute, Tampa, Florida, United States of America Abstract Background: Pancreatic cancer is one of the most aggressive cancers, with tumor-induced myeloid-derived suppressor cells (MDSC) contributing to its pathogenesis and ineffective therapies. In response to cytokine/chemokine receptor activation, src homology 2 domain-containing inositol 59-phosphatase-1 (SHIP-1) influences phosphatidylinositol-3-kinase (PI3K) signaling events, which regulate immunohomeostasis. We hypothesize that factors from murine pancreatic cancer cells cause the down-regulation of SHIP-1 expression, which may potentially contribute to MDSC expansion, and the suppression of CD8+ T cell immune responses. Therefore, we sought to determine the role of SHIP-1 in solid tumor progression, such as murine pancreatic cancer. Methodology and Principal Findings: Immunocompetent C57BL/6 mice were inoculated with either murine Panc02 cells (tumor-bearing [TB] mice) or Phosphate Buffer Saline (PBS) (control mice). Cytometric Bead Array (CBA) analysis of supernatants of cultured Panc02 detected pro-inflammatory cytokines such as IL-6, IL-10 and MCP-1. TB mice showed a significant increase in serum levels of pro-inflammatory factors IL-6
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