murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years小鼠海马神经发生在人类整个生命周期的特点,从0到100年.pdfVIP
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murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years小鼠海马神经发生在人类整个生命周期的特点,从0到100年
Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years 1 1,2 1 1 1,3 1 Rolf Knoth , Ilyas Singec , Margarethe Ditter , Georgios Pantazis , Philipp Capetian , Ralf P. Meyer , 4 1 4 Volker Horvat , Benedikt Volk , Gerd Kempermann * 1 Department of Neuropathology, University of Freiburg, Freiburg, Germany, 2 Burnham Institute for Medical Research, Stem Cell and Regeneration Program, La Jolla, California, United States of America, 3 Laboratory of Molecular Neurosurgery, Department of Stereotactic and Functional Neurosurgery, University of Freiburg, Freiburg, Germany, 4 CRTD – Center for Regenerative Therapies Dresden, Dresden, Germany Abstract Background: Essentially all knowledge about adult hippocampal neurogenesis in humans still comes from one seminal study by Eriksson et al. in 1998, although several others have provided suggestive findings. But only little information has been available in how far the situation in animal models would reflect the conditions in the adult and aging human brain. We therefore here mapped numerous features associated with adult neurogenesis in rodents in samples from human hippocampus across the entire lifespan. Such data would not offer proof of adult neurogenesis in humans, because it is based on the assumption that humans and rodents share marker expression patterns in adult neurogenesis. Nevertheless, together the data provide valuable information at least about the presence of markers, for which a link to adult neurogenesis might more reasonably be assumed than for others, in the adul
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