molecular determinants of ebola virus virulence in mice埃博拉病毒在小鼠毒性分子的决定因素.pdfVIP

Molecular Determinants of Ebola Virus Virulence in Mice 1,2,3 2,4 5 3,6 7 3,8 Hideki Ebihara , Ayato Takada , Darwyn Kobasa , Steven Jones , Gabriele Neumann , Steven Theriault , Mike Bray9, Heinz Feldmann3,8, Yoshihiro Kawaoka1,2,7,10* 1 Institute of Medical Science, University of Tokyo, Tokyo, Japan, 2 CREST, Japan Science and Technology Agency, Saitama, Japan, 3 Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, 4 Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan, 5 Respiratory Viruses, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, 6 Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada, 7 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 8 Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada, 9 Biodefense Clinical Research, Office of Clinical Research, Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 10 International Research Center for Infectious Diseases, Tokyo, Japan Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive. While adult mice resist ZEBOV infection, the Mayinga strain of the virus has been adapted to cause lethal infection in these animals. To understand the pathogenesis underlying the extreme virulence of Ebola virus (EBOV), here we identified the muta