identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine krasg12d-induced skin carcinogenesis in vivo识别表皮pdx1表达式揭示不同角色的notch1和notch2在小鼠体内krasg12d-induced皮肤致癌作用.pdfVIP

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identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine krasg12d-induced skin carcinogenesis in vivo识别表皮pdx1表达式揭示不同角色的notch1和notch2在小鼠体内krasg12d-induced皮肤致癌作用.pdf

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identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine krasg12d-induced skin carcinogenesis in vivo识别表皮pdx1表达式揭示不同角色的notch1和notch2在小鼠体内krasg12d-induced皮肤致癌作用

Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine KrasG12D-Induced Skin Carcinogenesis In Vivo 1 ¨ 1 2 3 4 Pawel K. Mazur , Barbara M. Gruner , Hassan Nakhai , Bence Sipos , Ursula Zimber-Strobl , Lothar J. 4 5 1 1 Strobl , Freddy Radtke , Roland M. Schmid , Jens T. Siveke * 1 2nd Department of Internal Medicine, Klinikum Rechts der Isar University Hospital, Technical University of Munich, Munich, Germany, 2 Department of Biological ¨ ¨ Sciences, University of Warwick, Coventry, United Kingdom, 3 Institute of Pathology, University Hospital, University of Tubingen, Tubingen, Germany, 4 Department of ´ ´ Gene Vectors, Helmholtz Zentrum, German Research Center for Environmental Health, Munich, Germany, 5 ISREC, Ecole Polytechnique Federale de Lausanne (EPFL SV ISREC), Lausanne, Switzerland Abstract Background: The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor cell population, Pdx1-Cre mice were utilized to generate conditional oncogenic KrasG12D mice with ablation of Notch1 and/or Notch2. Methodology/Principal Findings: Surprisingly, mice with activated KrasG12D and Notch1 but not Notch2 ablation developed skin papillomas progressi