有哪些信誉好的足球投注网站mri correlates of disability in african-americans with multiple sclerosis核磁共振相关的残疾在多发性硬化症的非洲裔美国人.pdfVIP
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mri correlates of disability in african-americans with multiple sclerosis核磁共振相关的残疾在多发性硬化症的非洲裔美国人
MRI Correlates of Disability in African-Americans with Multiple Sclerosis 1 3 2 2 2,4 Jonathan Howard , Marco Battaglini , James Scott Babb , Donatello Arienzo , Brigitte Holst , 1 3 1 1,2,5 Mirza Omari , Nicola De Stefano , Joseph Herbert , Matilde Inglese * 1 Department of Neurology, Langone Medical Center, New York, New York, United States of America, 2 Department of Radiology, Langone Medical Center, New York, New York, United States of America, 3 Department of Neurological and Behavioural Sciences, University of Siena, Siena, Italy, 4 Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5 Department of Neurology Mount Sinai School of Medicine, New York, New York, United States of America Abstract Objectives: Multiple sclerosis (MS) in African-Americans (AAs) is characterized by more rapid disease progression and poorer response to treatment than in Caucasian-Americans (CAs). MRI provides useful and non-invasive tools to investigate the pathological substrate of clinical progression. The aim of our study was to compare MRI measures of brain damage between AAs and CAs with MS. Methods: Retrospective analysis of 97 AAs and 97 CAs with MS matched for age, gender, disease duration and age at MRI examination. Results: AA patients had significantly greater T2- (p = 0.001) and T1-weighted (p = 0.0003) lesion volumes compared to CA patients. In contrast, measurements of global and regional brain volume did not significantly differ between the two ethnic groups (p.0.1). Conclusions: By studying a quite large sample
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