mri-based volumetry correlates of autobiographical memory in alzheimers diseasemri容量分析与自传记忆的阿尔茨海默氏症.pdfVIP

MRI-Based Volumetry Correlates of Autobiographical Memory in Alzheimer’s Disease 1,2 3 1 ´ 1 ´ 3 3 Nathalie Philippi *, Vincent Noblet , Anne Botzung , Olivier Despres , Felix Renard , Giorgos Sfikas , 1,2 ´ 4 1 ´ ´ 1,2 Benjamin Cretin , Stephane Kremer , Lilianne Manning , Frederic Blanc ´ 1 Laboratoire d’Imagerie et de Neurosciences Cognitives (UMR 7237), Universite de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France, 2 Service ´ de Neurologie - Unite de Neuropsychologie, Centre Hospitalo-Universitaire de Strasbourg, Strasbourg, France, 3 Laboratoire des Sciences de l’Image, de l’Informatique et ´ ´ ´ ´ de la Teledetection (UMR 7005), Universite de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France, 4 Service de Radiologie, Centre Hospitalo- Universitaire de Strasbourg, Strasbourg, France Abstract The aim of the present volumetric study was to explore the neuro-anatomical correlates of autobiographical memory loss in Alzheimer’s patients and healthy elderly, in terms of the delay of retention, with a particular interest in the medial temporal lobe structures. Fifteen patients in early stages of the disease and 11 matched control subjects were included in the study. To assess autobiographical memory and the effect of the retention delay, a modified version of the Crovitz test was used according to five periods of life. Autobiographical memory deficits were correlated to local atrophy via structural MRI using Voxel Ba