mri pattern recognition in multiple sclerosis normal-appearing brain areas磁共振成像模式识别在多发性硬化症正常大脑区域.pdfVIP
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mri pattern recognition in multiple sclerosis normal-appearing brain areas磁共振成像模式识别在多发性硬化症正常大脑区域
MRI Pattern Recognition in Multiple Sclerosis Normal- Appearing Brain Areas 1 . 1. ¨ 2 2,3 Martin Weygandt * , Kerstin Hackmack , Caspar Pfuller , Judith Bellmann-Strobl , Friedemann 2,3,4 5 1,6 Paul , Frauke Zipp , John-Dylan Haynes ´ ´ 1 Bernstein Center for Computational Neuroscience Berlin, Charite - University Medicine, Berlin, Germany, 2 NeuroCure Clinical Research Center, Charite - University ´ Medicine Berlin, Berlin, Germany, 3 Experimental and Clinical Research Center, Charite - University Medicine Berlin, Berlin, Germany, 4 Clinical and Experimental Multiple ´ Sclerosis Research Center, Charite - University Medicine Berlin, Berlin, Germany, 5 Department of Neurology, University Medicine Mainz, Johannes Gutenberg University, Mainz, Germany, 6 Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Abstract Objective: Here, we use pattern-classification to investigate diagnostic information for multiple sclerosis (MS; relapsing- remitting type) in lesioned areas, areas of normal-appearing grey matter (NAGM), and normal-appearing white matter (NAWM) as measured by standard MR techniques. Methods: A lesion mapping was carried out by an experienced neurologist for Turbo Inversion Recovery Magnitude (TIRM) images of individual subjects. Combining this mapping with templates from a neuroanatomic a
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