mri detects brain reorganization after human umbilical tissue-derived cells (hutc) treatment of stroke in rat核磁共振检测大脑重组后人类脐tissue-derived细胞(hutc)在大鼠治疗中风.pdfVIP

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mri detects brain reorganization after human umbilical tissue-derived cells (hutc) treatment of stroke in rat核磁共振检测大脑重组后人类脐tissue-derived细胞(hutc)在大鼠治疗中风.pdf

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mri detects brain reorganization after human umbilical tissue-derived cells (hutc) treatment of stroke in rat核磁共振检测大脑重组后人类脐tissue-derived细胞(hutc)在大鼠治疗中风

MRI Detects Brain Reorganization after Human Umbilical Tissue-Derived Cells (hUTC) Treatment of Stroke in Rat 1,6 4 4 1 1 Quan Jiang *, Christine Thiffault , Brian C. Kramer , Guang Liang Ding , Li Zhang , Siamak P. Nejad- 1 1 3 2 5 5 4 Davarani , Lian Li , Ali S. Arbab , Mei Lu , Brad Navia , Stephen J. Victor , Klaudyne Hong , Qing 1 1 1 1,6 Jiang Li , Shi Yang Wang , Yi Li , Michael Chopp 1 Department of Neurology, Henry Ford Health System, Detroit, Michigan, United States of America, 2 Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, United States of America, 3 Department of Radiology, Henry Ford Health System, Detroit, Michigan, United States of America, 4 Advanced Technologies and Regenerative Medicine, LLC, a Johnson Johnson Company, Somerville, New Jersey, United States of America, 5 Johnson Johnson Pharmaceutical Research and Development, Titusville, New Jersey, United States of America, 6 Department of Physics, Oakland University, Rochester, Michigan, United States of America Abstract Human umbilical tissue-derived cells (hUTC) represent an attractive cell source and a potential technology for neurorestoration and improvement of functional outcomes following stroke. Male Wistar rats were subjected to a transient middle cerebral artery occlusion (tMCAo) and were intravenously administered hUTC (N = 11) or vehicle (N = 10) 48 hrs after stroke. White matter and vascular reorganization was monitored over a 12-week period using MRI and histopathology. MRI results were correlated with