identification and characterization of bacterial vaginosis-associated pathogens using a comprehensive cervical-vaginal epithelial coculture assay细菌vaginosis-associated病原体的识别和描述使用一个全面cervical-vaginal上皮coculture化验.pdfVIP

Identification and Characterization of Bacterial Vaginosis-Associated Pathogens Using a Comprehensive Cervical-Vaginal Epithelial Coculture Assay 1 1 1 2 3 Colleen R. Eade , Camila Diaz , Matthew P. Wood , Kathryn Anastos , Bruce K. Patterson , 4 1 1 Phalguni Gupta , Amy L. Cole , Alexander M. Cole * 1 Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America, 2 Departments of Medicine and Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America, 3 Department of Pathology, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Palo Alto, California, United States of America, 4 Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Bacterial vaginosis (BV) is the most commonly treated female reproductive tract affliction, characterized by the displacement of healthy lactobacilli by an overgrowth of pathogenic bacteria. BV can contribute to pathogenic inflammation, preterm birth, and susceptibility to sexually transmitted infections. As the bacteria responsible for BV pathogenicity and their interactions with host immunity are not understood, we sought to evaluate the effects of BV- associated bacteria on reproductive epithelia. Here we have characterized the interaction between BV-associated bacteria and the fe