有哪些信誉好的足球投注网站horizontal gene transfers link a human mrsa pathogen to contagious bovine mastitis bacteria水平基因转移联系人类病原体耐甲氧西林金黄色葡萄球菌细菌传染性牛乳腺炎.pdfVIP
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horizontal gene transfers link a human mrsa pathogen to contagious bovine mastitis bacteria水平基因转移联系人类病原体耐甲氧西林金黄色葡萄球菌细菌传染性牛乳腺炎
Horizontal Gene Transfers Link a Human MRSA Pathogen to Contagious Bovine Mastitis Bacteria 1 2 2 1 1 1 Thomas Brody *, Amarendra S. Yavatkar , Yong Lin , Jermaine Ross , Alexander Kuzin , Mukta Kundu , 2 1 Yang Fann , Ward F. Odenwald * 1The Neural Cell-Fate Determinants Section, National Institutes of Health (NIH), Bethesda, Maryland, United States of America, 2 The Division of Intramural Research Information Technology Program, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, United States of America Abstract Background: Acquisition of virulence factors and antibiotic resistance by many clinically important bacteria can be traced to horizontal gene transfer (HGT) between related or evolutionarily distant microflora. Comparative genomic analysis has become an important tool for identifying HGT DNA in emerging pathogens. We have adapted the multi-genome alignment tool EvoPrinter to facilitate discovery of HGT DNA sequences within bacterial genomes and within their mobile genetic elements. Principal Findings: EvoPrinter analysis of 13 different Staphylococcus aureus genomes revealed that one of the human isolates, the hospital epidemic methicillin-resistant MRSA252 strain, uniquely shares multiple putative HGT DNA sequences with different causative agents of bovine mastitis that are not found in the other human S. aureus isolates. MRSA252 shares over 14 different DNA sequence blocks with the bovine mastitis ET3 S. aureus strain RF122, and many of the HGT DNAs encode virulence factors. EvoPrinter analysis of the MRSA252 chromosome also uncovered virulence-factor enc
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