hooray for hypoxia缺氧万岁.pdfVIP

Open access, freely available online Perspectives Hooray for Hypoxia? A new study comes to a counter-intuitive conclusion: hypoxia may have its benefi ts for patients with lung injury Geoff Bellingan The Risks of Hypoxia and animal studies showing Hyperoxia harm from giving 100% oxygen, the lungs are Hypoxaemia kills. Recently we have usually normal at the shown, in a study of over 50 000 beginning of the study, critically ill patients, that mortality so the arterial oxygen is rises steadily as the partial pressure correspondingly high— of arterial oxygen (PaO2) falls below typically a PaO2 of 40 about 11 kPa (80 mm Hg) (Figure 1) kPa (300 mm Hg); thus, [1]. Rats exposed to hypoxic conditions it may be the high PaO2 develop a mild infl ammatory response rather than the high with increased capillary leak and pro- percentage of inspired infl ammatory cytokine release [2]. oxygen that causes Hypoxia increases leukocyte adhesion, lung damage.) Some prolongs neutrophil survival, enhances researchers question the pro-infl ammatory responses (in