有哪些信誉好的足球投注网站identification and characterization of a novel multipotent sub-population of sca-1+ cardiac progenitor cells for myocardial regeneration识别和描述的一种新型多功能子总体中本来就+心脏祖细胞心肌再生.pdfVIP
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identificationandcharacterizationofanovelmultipotentsub-populationofsca-1cardiacprogenitorcellsformyocardialregeneration识别和描述的一种新型多功能子总体中本来就心脏祖细胞心肌再生
Identification and Characterization of a Novel Multipotent Sub-Population of Sca-1+ Cardiac Progenitor Cells for Myocardial Regeneration Michitaka Takamiya, Khawaja H. Haider, Muhammad Ashraf* Department of Pathology, University of Cincinnati, Cincinnati, Ohio, United States of America Abstract Methods and Results: The cardiac stem/progenitor cells from adult mice were seeded at low density in serum-free medium. The colonies thus obtained were expanded separately and assessed for expression of stem cell antigen-1 (Sca-1). Two colonies each with high Sca-1 (CSH1; 95.9%; CSH2; 90.6%) and low Sca-1 (CSL1; 37.1%; CSL2; 17.4%) expressing cells were selected for further studies. Sca-1+ cells (98.4%) isolated using Magnetic Cell Sorting System (MACS) from the hearts were used as a control. Although the selected populations were similar in surface marker expression (low in c-kit, CD45, CD34, CD31 and high in CD29), these cells exhibited diverse differentiation potential. Unlike CSH1, CSH2 expressed Nanog, TERT, Bcrp1, Nestin, Musashi1 and Isl-1, and also showed differentiation into osteogenic, chondrogenic, smooth muscle, endothelial and cardiac lineages. MACS sorted cells exhibited similar tendency albeit with relatively weaker differentiation potential. Transplantation of CSH2 cells into infarcted heart showed attenuated infarction size, significantly preserved left ventricular function and anterior wall thickness, and increased capillary density. We also observed direct differentiation of transplanted cells into endothelium and cardiomyocytes. Conclusions: The cardiac stem/progenitor cells isolated by a combined clonal selection and surface marker approach possessed multiple stem cell features important for cardiac regeneration. Citation: Takamiya M, Haider KH, Ashraf M (2011) Identification and Characterization
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