high prevalence of both humoral and cellular immunity to zaire ebolavirus among rural populations in gabon盛行的体液免疫和细胞免疫在加蓬扎伊尔ebolavirus在农村人口.pdfVIP

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high prevalence of both humoral and cellular immunity to zaire ebolavirus among rural populations in gabon盛行的体液免疫和细胞免疫在加蓬扎伊尔ebolavirus在农村人口.pdf

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high prevalence of both humoral and cellular immunity to zaire ebolavirus among rural populations in gabon盛行的体液免疫和细胞免疫在加蓬扎伊尔ebolavirus在农村人口

High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon 1,2. 1. ˜ 1 ´ 1 1 Pierre Becquart , Nadia Wauquier , Tanel Mahlakoiv , Dieudonne Nkoghe , Cindy Padilla , Marc 2,3 1 1 2 1 Souris , Benjamin Ollomo , Jean-Paul Gonzalez , Xavier De Lamballerie , Mirdad Kazanji , Eric M. Leroy1,2* ´ ´ 1 Unite des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon, 2 UMR190 Emergence des Pathologies Virales, ´ ´ Universite Aix-Marseille II Institut de Recherche pour le Developpement, Marseille, France, 3 Mahidol University at Salaya, Nakhonpathon, Thailand Abstract To better understand Zaire ebolavirus (ZEBOV) circulation and transmission to humans, we conducted a large serological survey of rural populations in Gabon, a country characterized by both epidemic and non epidemic regions. The survey lasted three years and covered 4,349 individuals from 220 randomly selected villages, representing 10.7% of all villages in Gabon. Using a sensitive and specific ELISA method, we found a ZEBOV-specific IgG seroprevalence of 15.3% overall, the highest ever reported. The seroprevalence rate was significantly higher in forested areas (19.4%) than in other ecosystems, namely grassland (12.4%), savannah (10.5%), and lakeland (2.7%). No other risk factors for seropositivity were found. The specificity of anti-ZEBOV IgG was confirmed by Western blot in 138 ind