granulocyte-colony stimulating factor (g-csf) in stroke patients with concomitant vascular disease—a randomized controlled trial粒细胞集落刺激因子(g - csf)在中风患者伴随的血管疫情。随机对照试验.pdfVIP

Granulocyte-Colony Stimulating Factor (G-CSF) in Stroke Patients with Concomitant Vascular Disease—A Randomized Controlled Trial 1,2,3 . 4. 4 4 4 Agnes Floel * , Tobias Warnecke , Thomas Duning , Yvonne Lating , Jan Uhlenbrock , Armin 5 5 5 6 4 ¨ ¨ 7 Schneider , Gerhard Vogt , Rico Laage , Winfried Koch , Stefan Knecht , Wolf-Rudiger Schabitz * ´ ¨ ´ ¨ 1 Department of Neurology, Charite-Universitatsmedizin Berlin, Berlin, Germany, 2 Center for Stroke Research Berlin, Charite-Universitatsmedizin Berlin, Berlin, Germany, ´ ¨ ¨ ¨ 3 Cluster of Excellence NeuroCure, Charite-Universitatsmedizin Berlin, Berlin, Germany, 4 Department of Neurology, University of Munster, Munster, Germany, 5 SYGNIS Bioscience, Heidelberg, Germany, 6 HAAPACS GmbH, Schriesheim, Germany, 7 Department of Neurology, Bethel, Evangelisches Krankenhaus Bielefeld (EVKB), Bielefeld, Germany Abstract Background: G-CSF has been shown in animal models of stroke to promote functional and structural regeneration of the central nervous system. It thus might present a therapy to promote recovery in the chronic stage after stroke. Methods: Here, we assessed the safety and tolerability of G-CSF in chronic stroke patients with concomitant vascular disease, and explored efficacy data. 41 patients were studied in a double-blind, randomized approach to either