有哪些信誉好的足球投注网站granulocyte colony-stimulating factor protects mice during respiratory virus infections粒细胞集落刺激因子保护老鼠在呼吸道病毒感染.pdfVIP
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granulocyte colony-stimulating factor protects mice during respiratory virus infections粒细胞集落刺激因子保护老鼠在呼吸道病毒感染
Granulocyte Colony-Stimulating Factor Protects Mice during Respiratory Virus Infections 1¤ 1 2 ´ 1,2 Tamar Hermesh , Thomas M. Moran , Deepika Jain , Carolina B. Lopez * 1 Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America, 2 Department of Pathobiology School of Veterinary Medicine and Institute for Immunology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Abstract A burst in the production of pro-inflammatory molecules characterizes the beginning of the host response to infection. Cytokines, chemokines, and growth factors work in concert to control pathogen replication and activate innate and adaptive immune responses. Granulocyte colony-stimulating factor (G-CSF) mobilizes and activates hematopoietic cells from the bone marrow, and it has been shown to mediate the generation of effective immunity against bacterial and fungal infections. G-CSF is produced at high levels in the lungs during infection with influenza and parainfluenza viruses, but its role during these infections is unknown. Here we show that during infection of mice with a non-lethal dose of influenza or Sendai virus, G-CSF promotes the accumulation of activated Ly6G+ granulocytes that control the extent of the lung pro- inflammatory response. Remarkably, these G-CSF-mediated effects facilitate viral clearance and sustain mouse survival. ´ Citation: Hermesh T, Moran TM, Jain D, Lopez CB (2012) Granulocyte Colony-Stimulating Factor Protects Mice during Respiratory Virus Infections. PLoS ONE 7(5): e37334. doi:10.1371/journal.pone.0037334 Editor: Bernhard Ryffel, Fr
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