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High Prevalence of HIV, HCV, HBV and Co-Infection and Associated Risk Factors among Injecting Drug Users in Yunnan Province, China 1,3. 1,3. 1 2 2 1,3 Yan-Heng Zhou , Zhi-Hong Yao , Feng-Liang Liu , Hong Li , Li Jiang , Jia-Wu Zhu , Yong- Tang Zheng1* 1 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China, 2 Yunnan Center for Disease Control and Prevention, Kunming, China, 3 The Graduate School of the Chinese Academy of Sciences, Beijing, China Abstract Objective: To estimate the prevalence of HIV, HCV, HBV and co-infection with 2 or 3 viruses and evaluate risk factors among injecting drug users (IDUs) in Yunnan province, China. Methods: 2080 IDUs were recruited from 5 regions of Yunnan Province, China to detect the infection status of HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV). Statistical analysis was performed to evaluate risk factors related to HIV, HCV and HBV infections. Results: The infection rates among all participants were 25.5% for HIV, 77.7% for HCV, 19.2% for HBV, 15% for HIV/HCV, 0.3% for HIV/HBV, 7.8% for HCV/HBV and 7.1% for HIV/HCV/HBV. The prevalence of virus infection varied widely by region in Yunnan of China. Statistical analyses indicated that high prevalence of HIV and HCV among IDUs was positively associated with the duration of drug injection and sharing needles/syringes; besides, HCV infection was associated with the frequency of drug injection. Conclusions: HIV, HCV, HBV infections and co-infections were still very prevalent among IDUs in Yunnan province because of drug use behaviors. Citation: Zhou Y-H, Yao Z-H, Liu F-L, Li H, Jiang