有哪些信誉好的足球投注网站granulocyte colony-stimulating factor (g-csf) protects oligpdendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats粒细胞集落刺激因子(g - csf)保护oligpdendrocyte和促进下肢功能恢复脊髓损伤后大鼠.pdfVIP
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granulocyte colony-stimulating factor (g-csf) protects oligpdendrocyte and promotes hindlimb functional recovery after spinal cord injury in rats粒细胞集落刺激因子(g - csf)保护oligpdendrocyte和促进下肢功能恢复脊髓损伤后大鼠
Granulocyte Colony-Stimulating Factor (G-CSF) Protects Oligpdendrocyte and Promotes Hindlimb Functional Recovery after Spinal Cord Injury in Rats 1 2 1 3 1 2 Ryo Kadota , Masao Koda *, Junko Kawabe , Masayuki Hashimoto , Yutaka Nishio , Chikato Mannoji , 1 1 1 1 1 Tomohiro Miyashita , Takeo Furuya , Akihiko Okawa , Kazuhisa Takahashi , Masashi Yamazaki 1 Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chuo-Ku, Chiba, Japan, 2 Department of Orthopaedic Surgery, Chiba Aoba Municipal Hospital, Chuo-Ku, Chiba, Japan, 3 Department of Orthopaedic Surgery, Chiba Medical Center, Chuo-Ku, Chiba, Japan Abstract Background: Granulocyte colony-stimulating factor (G-CSF) is a protein that stimulates differentiation, proliferation, and survival of cells in the granulocytic lineage. Recently, a neuroprotective effect of G-CSF was reported in a model of cerebral infarction and we previously reported the same effect in studies of murine spinal cord injury (SCI). The aim of the present study was to elucidate the potential therapeutic effect of G-CSF for SCI in rats. Methods: Adult female Sprague-Dawley rats were used in the present study. Contusive SCI was introduced using the Infinite Horizon Impactor (magnitude: 200 kilodyne). Recombinant human G-CSF (15.0 mg/kg) was administered by tail vein injection at 1 h after surgery and daily the next four days. The vehicle control rats received equal volumes of normal saline at the same time points. Results: Using a contusive SCI model to examine the neuroprotective pote
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