有哪些信誉好的足球投注网站granulocyte-colony stimulating factor (g-csf) improves motor recovery in the rat impactor model for spinal cord injury粒细胞集落刺激因子(g - csf)提高电动机的复苏为脊髓损伤鼠撞击器模型.pdfVIP
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granulocyte-colony stimulating factor (g-csf) improves motor recovery in the rat impactor model for spinal cord injury粒细胞集落刺激因子(g - csf)提高电动机的复苏为脊髓损伤鼠撞击器模型
Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury Tanjew Dittgen, Claudia Pitzer, Christian Plaas, Friederike Kirsch, Gerhard Vogt, Rico Laage, Armin Schneider* SYGNIS Bioscience, Heidelberg, Germany Abstract Granulocyte-colony stimulating factor (G-CSF) improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function. Citation: Dittgen T, Pitzer C, Plaas C, Kirsch F, Vogt G, et al. (2012) Granulocyte-Colony Stimulating Factor (G-CSF) Improves Motor Recovery in the Rat Impactor Model for Spinal Cord Injury. PLoS ONE 7(1): e29880. doi:10.1371/journal.pone.0029880 Editor: Colin Combs, University of North Dakota, United States of America Received September 9, 2010; Accepted December 6, 2011; Published January 12, 2012 Copyright: 2012 Dittgen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: No external grants were used for this study. Competing Interests: The authors have read the journal’s policy and have the following conflicts: AS is an inventor on patent applications claiming the use of G-CSF for spinal cord injury tre
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