geo-spatial hotspots of hemorrhagic fever with renal syndrome and genetic characterization of seoul variants in beijing, china地理空间热点地区肾综合征出血热,首尔和遗传特性的变异在北京,中国.pdfVIP

Geo-spatial Hotspots of Hemorrhagic Fever with Renal Syndrome and Genetic Characterization of Seoul Variants in Beijing, China 1 1 1 1 1 2 2 Shu-Qing Zuo , Li-Qun Fang , Lin Zhan , Pan-He Zhang , Jia-Fu Jiang , Li-Ping Wang , Jia-Qi Ma , Bing- 3 4 1 1 1 1 Cai Wang , Ri-Min Wang , Xiao-Ming Wu , Hong Yang , Zhi-Wei Cao , Wu-Chun Cao * 1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China, 2 Centers for Public Health Information, Center for Disease Control and Prevention, Beijing, China, 3 Beijing Haidian Centers for Disease Control and Prevention, Beijing, China, 4 Beijing Dongcheng Centers for Disease Control and Prevention, Beijing, China Abstract Background: Hemorrhagic fever with renal syndrome (HFRS) is highly endemic in mainland China, and has extended from rural areas to cities recently. Beijing metropolis is a novel affected region, where the HFRS incidence seems to be diverse from place to place. Methodology/Principal Findings: The spatial scan analysis based on geographical information system (GIS) identified three geo-spatial ‘‘hotspots’’ of HFRS in Beijing when the passive surveillance data from 2004 to 2006 were used. The Relative Risk (RR) of the three ‘‘hotspots’’ was 5.45, 3.57 and 3.30, respectively. The Phylogenetic analysis based on entire coding region sequence of S segment and partial L segment sequence of Seoul virus (SEOV) revealed that the SEOV strains circulating in Beijing could be classified into at least three lineages regardless of their host origins. Two potential recombination events that happened in lineage #1 were detected and