genetic polymorphisms of gstm1, gstt1, and gstp1 with prostate cancer risk a meta-analysis of 57 studiesgstt1,gstm1基因的遗传多态性与前列腺癌风险问题57研究的荟萃分析.pdfVIP

Genetic Polymorphisms of GSTM1, GSTT1, and GSTP1 with Prostate Cancer Risk: A Meta-Analysis of 57 Studies 1. 2. 3 4 5 1 Mancheng Gong , Wenjing Dong , Zhirong Shi , Yangyang Xu , Wenjun Ni , Ruihua An * 1 Department of Urological Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China, 2 Department of Oncology, The First Affiliated Hospital of Harbin Medical University, Harbin, China, 3 Department of Pharmacy, The Second People’s Hospital of Zhuhai, Zhuhai, China, 4 Department of Urological Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China, 5 Department of Urological Surgery, The Hei Longjiang Hospital, Harbin, China Abstract Background and Objectives: The GSTM1, GSTT1 and GSTP1 polymorphisms might be involved in inactivation of procarcinogens that contribute to the genesis and progression of cancers. However, studies investigating the association between GSTM1, GSTT1 or GSTP1 polymorphisms and prostate cancer (PCa) risk report conflicting results, therefore, we conducted a meta-analysis to re-examine the controversy. Methods: Published literature from PubMed, Embase, Google Scholar and China National Knowledge Infrastructure (CNKI) were searched (updated to June 2, 2012). According to our inclusion criteria, studies that observed the association between GSTM1, GSTT1 or GSTP1 polymorphisms and PCa risk were included. The principal outcome measure was the odds ratio (OR) with 95% confidence interval (CI) for the risk of PCa associated with GSTM1, GSTT1 and GSTP1 polymorphisms. Results: Fifty-seven studies involving 11313 cases and 12934 controls were recruited. The overall OR, which was 1.2854 (95% CI = 1.1405–1.4487), rev