genetic population structure analysis in new hampshire reveals eastern european ancestry基因在新罕布什尔州人口结构分析揭示了东欧血统.pdfVIP

Genetic Population Structure Analysis in New Hampshire Reveals Eastern European Ancestry 1 2 2,4,5 6 2 Chantel D. Sloan , Angeline D. Andrew , Eric J. Duell , Scott M. Williams , Margaret R. Karagas , Jason H. Moore1* 1 Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 2 Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 3 Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 4 Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, International Agency for Research on Cancer, Lyon, ` France, 5 Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme Institut Catala d’Oncologia (ICO) Catalan Institute of Oncology, L’Hospitalet de Llobregat, Barcelona, Spain, 6 Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America Abstract Genetic structure due to ancestry has been well documented among many divergent human populations. However, the ability to associate ancestry with genetic substructure without using supervised clustering has not been explored in more presumably homogeneous and admixed US populations. The goal of this study was to determine if genetic structure could be detected in a United States population from a single state where the individuals have mixed European ancestry. Using Bayesian clustering with a set of 960 single nucleotide polymorphisms (SNPs) we found evidence of population stratification in