有哪些信誉好的足球投注网站genetic polymorphisms of estrogen receptors α and β and the risk of developing prostate cancer雌激素受体α和β基因多态性和患前列腺癌的风险.pdfVIP
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genetic polymorphisms of estrogen receptors α and β and the risk of developing prostate cancer雌激素受体α和β基因多态性和患前列腺癌的风险
Genetic Polymorphisms of Estrogen Receptors a and b and the Risk of Developing Prostate Cancer 1,2 2,3 2 2 2,4 Young Kwang Chae *, Han-Yao Huang , Paul Strickland , Sandra C. Hoffman , Kathy Helzlsouer 1 Department of Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania; United States of America, 2 Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, 3 Outcomes Research and Management, Merck Co., West Point, Pennsylvania, United States of America, 4 The Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, United States of America Abstract Estrogen may be involved in the development of prostate cancer. The association between genetic polymorphisms of estrogen receptors a (ESR1) and b (ESR2) and prostate cancer risk was examined in a nested case-control study in Washington County, Maryland. Incident prostate cancer cases (n = 269) were matched to one or two controls (n = 440) by age, sex, race, and date of blood donation. Associations between estrogen receptor genotypes or dietary intake and the development of prostate cancer were examined in conditional logistic regression models. Results from this study showed that six single base-pair polymorphisms (SNPs) of ESR1 (rs1801132, rs2077647, rs746432, rs2273206, rs851982, rs2228480) and four SNPs of ESR2 (rs4986938, rs928554, rs8018687, rs number not available for ESR2 5696 bp 39 of STP A.G) were not significantly associated with prostate cancer risk, either by allelic or genotypic frequencies. However, an interactive association with BMI was observed in the relationship between
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