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genetic prediction of future type 2 diabetes未来的2型糖尿病的基因预测
Open access, freely available online PLoS MEDICINE Genetic Prediction of Future Type 2 Diabetes 1* 1 1,2 1 ¨ 1 3,4 Valeriya Lyssenko , Peter Almgren , Dragi Anevski , Marju Orho-Melander , Marketa Sjogren , Carola Saloranta , Tiinamaija Tuomi3,4 1 , Leif Groop , the Botnia Study Group ¨ ¨ 1 Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden, 2 School of Mathematical Sciences, Chalmers ¨ University of Technology, Gothenburg, Sweden, 3 Department of Medicine, Division of Diabetology, Helsinki University Hospital, Helsinki, Finland, 4 Folkhalsan Research Center, Institute of Genetics, Helsinki, Finland Competing Interests: LG is a A B S T R A C T member of the editorial board of PLoS Medicine. Background Author Contributions: VL extracted, genotyped, and analyzed the data, Type 2 diabetes (T2D) is a multifactorial disease in which environmental triggers interact with and drafted the report. PA and DA genetic variants in the predisposition to the disease. A number of common variants have been were responsible for the statistical associated with T2D but our knowledge of their ability to predict T2D prospectively is limited.
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