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Genetic Polymorphisms of Glutathione S-Transferase Genes GSTM1, GSTT1 and Risk of Hepatocellular Carcinoma 1. 2. 3 3 Kang Song , Jiayong Yi , Xizhong Shen *, Yu Cai * 1 Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China, 2 Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China, 3 Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China Abstract Background: A number of case-control studies were conducted to investigate the association of glutathione S-transferase (GST) genetic polymorphisms and hepatocellular carcinoma (HCC) risk. However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between polymorphisms on GSTM1, GSTT1 and HCC. Methodology/Prinicpal Findings: PubMed, EMBASE, ISI web of science and the CNKI databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess the strength of association. Potential sources of heterogeneity were also assessed by subgroup analysis and meta-regression. Funnel plots and Egger’s linear regression were used to test publication bias among the articles. A total of 34 studies including 4,463 cases and 6,857 controls were included in this meta-analysis. In a combined analysis, significantly increased HCC risks were found for null genotype of GSTM1 (OR = 1.29, 95% CI: 1.06–1.58; P = 0.01) and GSTT1 (OR = 1.43, 95% CI: 1.22–1.68; P,1025). Potential sources of heterogeneity were explored by subgroup analysis and meta