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genome-wide co-expression analysis in multiple tissues全基因组co-expression分析在多个组织
Genome-Wide Co-Expression Analysis in Multiple Tissues 1 1,2 3,4 3,4 5 Ian C. Grieve , Nicholas J. Dickens , Michal Pravenec , Vladimir Kren , Norbert Hubner , Stuart A. 1,6 1 1,7 1 Cook , Timothy J. Aitman , Enrico Petretto *, Jonathan Mangion 1 MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, United Kingdom, 2 Institute of Cancer Research, Belmont, Sutton, Surrey, United Kingdom, 3 Institute of Biology and Medical Genetics, First Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic, 4 Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic, 5 Max-Delbru˝ck-Center for Molecular Medicine, Berlin-Buch, Berlin, Germany, 6 National Heart and Lung Institute, Imperial College, London, United Kingdom, 7 Division of Epidemiology, Public Health and Primary Care, Imperial College, London, United Kingdom Abstract Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis- and trans-acting, reflecting local and distant regulation of gene expression respectively. Although there is evidence of co- regulation within clusters of trans-eQTLs, the extent of co-expression patterns and their relationship with the genotypes at eQTLs are not fully understood. We have mapped thousands of cis- and trans-eQTLs in four tissues (fat, kidney, adrenal and left ventricle) in a large panel of rat recombinant inbred (RI) strains. Here we investigate the genome-wide correlation structure in expression levels of eQTL transcripts and underlying
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