genome-wide dna methylation and gene expression analyses of monozygotic twins discordant for intelligence levels全基因组dna甲基化和基因表达分析的同卵双胞胎的智力水平.pdfVIP

Genome-Wide DNA Methylation and Gene Expression Analyses of Monozygotic Twins Discordant for Intelligence Levels 1. 1. 1 2 1 Chih-Chieh Yu , Mari Furukawa , Kazuhiro Kobayashi , Chizuru Shikishima , Pei-Chieng Cha , 3 4 5 4 6 1 Jun Sese , Hiroko Sugawara , Kazuya Iwamoto , Tadafumi Kato , Juko Ando , Tatsushi Toda * 1 Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe University, Kobe, Japan, 2 Keio Advance Research Centers, Keio University, Tokyo, Japan, 3 Department of Computer Science, Graduate School of Information Science and Engineering, Tokyo Institute of Technology, Tokyo, Japan, 4 Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan, 5 Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 6 Faculty of Letters, Keio University, Tokyo, Japan Abstract Human intelligence, as measured by intelligence quotient (IQ) tests, demonstrates one of the highest heritabilities among human quantitative traits. Nevertheless, studies to identify quantitative trait loci responsible for intelligence face challenges because of the small effect sizes of individual genes. Phenotypically discordant monozygotic (MZ) twins provide a feasible way to minimize the effects of irrelevant genetic and environmental factors, and should yield more interpretable results by finding epigenetic or gene expression differences between twins. Here we conducted array-based genome-wide DNA methylation and gene expression analyses using 17 pa