generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza a h5n1 viruses一代,表征和抗原决定基映射两个中和和保护人类重组甲型h5n1流感病毒的抗体.pdfVIP

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generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza a h5n1 viruses一代,表征和抗原决定基映射两个中和和保护人类重组甲型h5n1流感病毒的抗体.pdf

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generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza a h5n1 viruses一代,表征和抗原决定基映射两个中和和保护人类重组甲型h5n1流感病毒的抗体

Generation, Characterization and Epitope Mapping of Two Neutralizing and Protective Human Recombinant Antibodies against Influenza A H5N1 Viruses 1 2 1 3 1 3 1 3 1 Lina Sun , Xiuhua Lu , Chuan Li , Min Wang , Qinzhi Liu , Zi Li , Xiaofen Hu , Jiandong Li , Feng Liu , 4 2 2 3 2 1 Qun Li , Jessica A. Belser , Kathy Hancock , Yuelong Shu , Jacqueline M. Katz , Mifang Liang *, Dexin Li3* 1 State Key Laboratory for Infectious Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China, 2 Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 3 State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China, 4 Anhui Provincial Center for Disease Control and Prevention, Heifei, China Abstract Background: The development of new therapeutic targets and strategies to control highly pathogenic avian influenza (HPAI) H5N1 virus infection in humans is urgently needed. Broadly cross-neutralizing recombinant human antibodies obtained from the survivors of H5N1 avian influenza provide an important role in immunotherapy for human H5N1 virus infection and definition of the critical epitopes for vaccine development. Methodology/Principal Findings: We have characterized two recombinant baculovirus-expressed human antibodies (rhAbs), AVFluIgG01 and AVFluIgG03, generated by sc