genome-wide divergence of dna methylation marks in cerebral and cerebellar cortices全基因组dna甲基化的差异是在大脑和小脑皮质.pdfVIP

Genome-Wide Divergence of DNA Methylation Marks in Cerebral and Cerebellar Cortices 1 1 2,3 1 1 1,4 Yurong Xin , Benjamin Chanrion , Meng-Min Liu , Hanga Galfalvy , Ramiro Costa , Boro Ilievski , 1,4,5 1 1,2,4 1,4 2,3 Gorazd Rosoklija , Victoria Arango , Andrew J. Dwork , J. John Mann , Benjamin Tycko , Fatemeh Haghighi1* 1 Department of Psychiatry, Columbia University and The New York State Psychiatric Institute, New York, New York, United States of America, 2 Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America, 3 Taub Institute for Research on the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America, 4 School Of Medicine, University Ss. Cyril and Methodius, Skopje, Macedonia, 5 Macedonian Academy of Sciences and Arts, University Ss. Cyril and Methodius, Skopje, Macedonia Abstract Background: Emerging evidence suggests that DNA methylation plays an expansive role in the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of the normal human brain offers tremendous potential in understanding the role of DNA methylation in brain development and function. Methodology/Significant Findings: Using methylation-sensitive SNP chip analysis (MSNP), we performed whole genome DNA methylation profiling of the prefrontal, occipital, and temporal regions of cerebral cortex, as well as cerebellum. These data provide an unbias