有哪些信誉好的足球投注网站genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy kashin-beck disease全基因组基因表达分析显示缺氧的一个重要的角色在流行osteochondropathy大骨节病的发病机理.pdfVIP
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genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy kashin-beck disease全基因组基因表达分析显示缺氧的一个重要的角色在流行osteochondropathy大骨节病的发病机理
Genome-Wide Gene Expression Analysis Suggests an Important Role of Hypoxia in the Pathogenesis of Endemic Osteochondropathy Kashin-Beck Disease 1 1 2 3 1 Feng Zhang *, Xiong Guo *, Weizhuo Wang , Hua Yan , Chunyan Li 1 Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Faculty of Public Health, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China, 2 Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China, 3 National Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi’an, Shaanxi, People’s Republic of China Abstract Kashin-Beck Disease (KBD) is an endemic osteochondropathy, the pathogenesis of which remains unclear now. In this study, we compared gene expression profiles of articular cartilage derived respectively from KBD patients and normal controls. Total RNA were isolated, amplified, labeled and hybridized to Agilent human 1A 22 k whole genome microarray chip. qRT- PCR was conducted to validate our microarray data. We detected 57 up-regulated genes (ratios $2.0) and 24 down- regulated genes (ratios #0.5) in KBD cartilage. To further identify the key genes involved in the pathogenesis of KBD, Bayesian analysis of variance for microarrays(BAM) software was applied and identified 12 potential key genes with an average ratio 6.64, involved in apoptosis, metabolism, cytokine growth factor and cytoskeleton cell movement. Gene Set Enrichment Analysis (GSEA) software was used to identify differently expressed gene ontology categories and pathways. GSEA found that a set of apoptosis, hypoxia and mitochondrial function related gene ontol
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