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generation of lung adenocarcinoma dna aptamers for cancer studies代的肺腺癌dna寡核苷酸适配子对癌症的研究
Generation of Lung Adenocarcinoma DNA Aptamers for Cancer Studies ´ 1 1 ´ ´ 1 1 2 Elizabeth Jimenez , Kwame Sefah , Dalia Lopez-Colon , Dimitri Van Simaeys , Hui William Chen , 3 1 Melvyn S. Tockman , Weihong Tan * 1 Department of Chemistry, University of Florida, Gainesville, Florida, United States of America, 2 Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, United States of America, 3 Department of Oncology Sciences, Moffitt Cancer Center, Tampa, Florida, United States of America Abstract Lung cancer is the most lethal malignancy in the world, and each year thousands of people die from this disease. Early detection has proven to increase the 5-year survival for this cancer in general, independent of the origination site in the lung. To address this challenge, we have used cell-based SELEX (Systematic Evolution of Ligands by Exponential Enrichment) to select a panel of aptamers capable of distinguishing lung adenocarcinoma cells from normal lung epithelial cells. These aptamers bind at physiological and formalin-fixed conditions and display affinity for their targets with apparent Kd’s in the nanomolar range. Our findings suggest that the selected aptamers have the potential to be used in clinical settings, as well as to improve classification of nonsurgical specimens, another current challenge in lung cancer. ´ ´ ´ Citation: Jimenez E, Sefah K, Lopez-Colon D, Van Simaeys D, Chen HW, et al. (2012) Generation of Lung Adenocarcinoma DNA Aptamers for Cancer Studies. PLoS ONE 7(10): e46222. doi:10.1371/journal.pone.0046222 Editor: Muy-Teck Teh, Barts The London School of
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