genetic variation in mdm2 and p14arf and susceptibility to salivary gland carcinoma遗传变异在mdm2和p14arf和唾腺癌易感性.pdfVIP

Genetic Variation in MDM2 and p14ARF and Susceptibility to Salivary Gland Carcinoma 1,2. 1 1,3. 4 1,4 1,4 Lei Jin , Li Xu , Xicheng Song , Qingyi Wei , Erich M. Sturgis , Guojun Li * 1 Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, 2 Department of Stomatology, Jinling Hospital, School of Medicine, Southern Medical University, Nanjing, China, 3 Department of Otorhinolaryngology and Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China, 4 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America Abstract Background: The p14ARF/MDM2/p53 pathway plays an important role in modulation of DNA damage and oxidative stress responses. The aim of this study was to determine whether genetic variants in MDM2 and p14ARF are associated with risk of salivary gland carcinoma (SGC). Methods: Four single nucleotide polymorphisms (SNPs) in MDM2 and p14ARF (MDM2-rs2279744, MDM2-rs937283, p14ARF- rs3731217, and p14ARF-rs3088440) were genotyped in 156 patients with SGC and 511 cancer-free controls. Multivariate logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: MDM2-rs2279744 was significantly associated with a moderately increased risk of SGC (OR, 1.5, 95% CI, 1.1–2.2). There was a trend toward significantly increased SGC risk with increasing number of risk genotypes of the four polymorphisms (Ptrend = 0.004). Individuals carrying 3–4 risk genotypes in MDM2 and p14ARF were at increased SGC risk (OR,