gene disruption of plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes基因破坏的恶性疟原虫疟疾p52导致衰减肝脏发展在人类肝细胞培养的初级阶段.pdfVIP
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gene disruption of plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes基因破坏的恶性疟原虫疟疾p52导致衰减肝脏发展在人类肝细胞培养的初级阶段
Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes 1 2 1 2 3,4 Ben C. L. van Schaijk , Chris J. Janse , Geert-Jan van Gemert , Melissa R. van Dijk , Audrey Gego , Jean- 3,4 1 3,4 3,4 Francois Franetich , Marga van de Vegte-Bolmer , Samir Yalaoui , Olivier Silvie , Stephen L. 5 2 3,4,6 1 2 Hoffman , Andrew P. Waters , Dominique Mazier , Robert W. Sauerwein , Shahid M. Khan * 1 Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 2 Department of Parasitology, Leiden University ´ Medical Centre, Leiden, The Netherlands, 3 INSERM, U511, Paris, France, 4 Universite Pierre et Marie Curie-Paris6, UMR S511 Paris, France, 5 Sanaria Inc., Rockville, ´ ˆ ` Maryland, United States of America, 6 AP-HP, Groupe hospitalier Pitie-Salpetriere, Service Parasitologie-Mycologie, Paris, France Abstract Difficulties with inducing sterile and long lasting protective immunity against malaria with subunit vaccines has renewed interest in vaccinations with attenuated Plasmodium parasites. Immunizations with sporozoites that are attenuated by radiation (RAS) ca
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