genetical genomics spotlight on qtl hotspots遗传的基因qtl热点置于聚光灯下.pdfVIP

Perspective Genetical Genomics: Spotlight on QTL Hotspots 1 1 1 1,2 3 4 5 Rainer Breitling , Yang Li , Bruno M. Tesson , Jingyuan Fu , Chunlei Wu , Tim Wiltshire , Alice Gerrits , 5 5 3 1,2 Leonid V. Bystrykh , Gerald de Haan , Andrew I. Su *, Ritsert C. Jansen * 1 Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, Haren, The Netherlands, 2 Department of Human Genetics, Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 3 Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, 4 School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America, 5 Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Genetical genomics aims at identifying with a minimum hotspot size of 50 target However, we suggest here that these quantitative trait loci (QTLs) for molecular genes. Furthermore, they demonstrated that observations may also be explained by traits such as gene expression or protein these hotspots are biologically coherent by clusters of genes with highly correlated levels (eQTL and pQTL, respectively). One showing that in about 25% of cases, the expression. If one gene shows a spurious of the central concepts in genetical geno- hotspot targets are enriched for