genetic variations in a ptenaktmtor axis and prostate cancer risk in a chinese population基因变异在ptenaktmtor轴和中国人口患前列腺癌的风险.pdfVIP

Genetic Variations in a PTEN/AKT/mTOR Axis and Prostate Cancer Risk in a Chinese Population 1. 1. 1. 1 1 1 1 2 Jiawei Chen , Pengfei Shao , Qiang Cao , Pu Li , Jie Li , Hongzhou Cai , Jian Zhu , Meilin Wang , 2 1 1 Zhengdong Zhang , Chao Qin *, Changjun Yin * 1 State Key Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2 Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China Abstract Backgroud: Genetic variations in a PTEN/AKT/mTOR signaling axis may influence cellular functions including cell growth, proliferation and apoptosis, and then increase the individual’s risk of cancer. Accordingly, we explore the association between single nucleotide polymorphisms (SNPs) of these genes and prostate cancer (PCa) in our Chinese population. Methods: Subjects were recruited from 666 PCa patients and 708 cancer-free controls, and eight SNPs in the PTEN/AKT/ mTOR axis were determined by the TaqMan assay. Odds ratios (OR) and 95% confidence intervals (95% CI) were evaluated by logistic regression. Results: We observed significant associations between PCa risk and mTOR rs2295080 [P = 0.027, OR = 0.85, 95%CI = 0.74– 0.98], and AKT2 rs7254617 (P = 0.003, OR = 1.35, 95%CI = 1.11–1.64). When estimated these two SNPs together, the combined genotypes with 2–4 risk alleles (rs2295080 T and rs7254617 A alleles) were associated with an increased risk of PCa compared with 0–1 risk alleles, which was more pronounced among subgroups of age .71 years, smokers, drinkers and n