1038例矮小症病因及治疗的研究.pdfVIP

吴 瑾等 1 038例矮小症病因及治疗的研究 第7期 · 947· 1 038例矮小症病因及治疗的研究 吴 瑾 向承发 王 栋 四川大学华西附二院儿科 (四川 成都) 610041 中国图书分类号 R725．8 文献标识码 A 文章编号 1001．4411(2008)07-0947-03 【摘 要】 目的：分析矮小症的病因及治疗特点，为该类患儿的诊断及治疗提供有价值的参考。方法：对1 038例矮小儿 童 (男511例，女527例)进行病因分析，并按是否缺乏生长激素 (growth hormone，GH)分为GH缺乏与非GH缺乏两组，分 别采用重组人生长激素 (rhGH)和非rhGH治疗。结果：1 038例患儿中，内分泌疾病所致矮小占大多数，最常见为生长激素缺 乏症 (growth hormone deficienty，GHD)295例，占28．4％，甲状腺功能低下217例，占20．9％，Turner综合征105例，占 10．1％，青春期发育延迟85例，占8．2％，宫内发育迟缓51例，占4．9％，家族性矮小45例，占4．3％，特发性矮小33例，占 3．2％，尿崩症伴GHD 23例，占2．2％，其余占21．3％。rhGH对GHD治疗效果满意1 cm／月左右，非GH缺乏组中甲状腺功能 低下予以甲状腺素片加赖氨酸合剂治疗，身高增长迅速，大约1 cm／月。结论：矮小原因很多，及时发现病因，寻求最佳治疗手 段非常重要。 【关键词】 矮小症 病因 治疗 Etiologic and remedial study of 1 03 8 children with short stature wu fin，XIANG Cheng—Fa，WANG Dong．Pediatric Department West China Second Hospital ofSichuan University， Chengdu 610041．China [Abstract] Objective：Analyzing the etiological factor and treatment feature of 1 038 children with short stature，to provide a wor- thy reference of di 、gnosis and treatment for those type of dwarfisms．Methods：1 038 children were collected，among them 5 1 1 were males (49．22％)，527 were females(50．78％)．All of the children were collected detail medical history and taken both physical and laboratory examinations．An d they were divided into two groups according to the level of growth hormone，one was GH lack group and the other was non — GH lack group，which were respectively adopted reorganization human growth hormone(rhGH)and non—rhGH treatment．Results： Endocrinopathy could cause short stature．GHD was the most common disease among the 1 038 children．There were 295 cases(28．4％)di— agnosed as growth hormone deficiency(GHD)，217 cases(20．9％)hypothyroidism，105 cases(10．1％)Turner syndrome，85 cases (8．2％)constitutional delay of growth and puberty，51 cases(4．9％)intrauterine growth retardation，45 cases(4．3％)familial short stature，33 cases(